No. There are currently no FDA-approved medications specifically for methamphetamine use disorder. Research is active, and some medication combinations have shown benefit in clinical trials, but they are not FDA-approved specifically for this condition.
What treatments do have evidence?
SAMHSA and other authorities emphasize behavioral treatments, especially contingency management, cognitive behavioral therapy, and motivational approaches. Contingency management uses structured incentives to reinforce treatment goals such as stimulant abstinence or attendance.
What about naltrexone plus bupropion?
A large NIH-supported clinical trial found that extended-release injectable naltrexone combined with oral bupropion improved outcomes for some adults with moderate or severe methamphetamine use disorder compared with placebo. The combination may be considered off label by clinicians in selected cases, but it is not FDA-approved specifically for methamphetamine use disorder.
Why has medication development been difficult?
Methamphetamine affects multiple brain systems, and stimulant use disorder can vary widely in pattern, psychiatric symptoms, and co-occurring substance use. No medication has yet met the FDA standard for an approved indication.
Does “no FDA-approved medication” mean treatment does not work?
No. Behavioral treatment can be effective, and treatment can also address sleep, depression, anxiety, psychosis, medical complications, housing, and other recovery needs.
Can medications still be used for co-occurring conditions?
Yes. Clinicians may prescribe medications for conditions such as depression, anxiety, ADHD, or other medical issues when appropriate. That is different from having an FDA-approved medication specifically for methamphetamine use disorder.
Trinity Behavioral Health provides information about adult residential addiction treatment. This article does not describe a specific Trinity medication protocol.
Frequently asked questions
Is there a methamphetamine equivalent of methadone or buprenorphine?
No FDA-approved equivalent currently exists for stimulant use disorder.
Is contingency management a medication?
No. It is a behavioral treatment.
Are researchers still testing medications?
Yes. NIH-supported research continues to evaluate medication and combination approaches.
Sources
This article is general education and does not replace individualized medical advice.