Acamprosate is an FDA-approved medication for alcohol use disorder that helps people maintain abstinence after they have stopped drinking. It does not treat acute alcohol withdrawal and does not make a person sick if alcohol is consumed.
How does acamprosate work?
Its exact mechanism is not fully understood, but it appears to help stabilize brain signaling that has been altered by chronic alcohol exposure. This may make it easier for some people to maintain abstinence.
When is acamprosate started?
Acamprosate is generally started after alcohol withdrawal has resolved and the person is abstinent. It is not intended to replace medically supervised withdrawal care.
Who may be a good candidate?
Clinicians consider treatment goals, kidney function, adherence, other medications, and overall health. Acamprosate can be especially relevant when the goal is continued abstinence.
Does acamprosate reduce cravings?
It may reduce the distress and craving associated with maintaining abstinence for some patients, although response varies.
Is acamprosate addictive?
No. It is not a controlled substance and does not produce intoxication.
Can it be combined with therapy?
Yes. Medication is commonly used alongside counseling, behavioral treatment, mutual aid, and other recovery supports.
See Trinity’s overview of medications used to treat alcohol use disorder. This article does not state that Trinity currently prescribes acamprosate; medication availability should be verified directly.
Frequently asked questions
Does acamprosate treat withdrawal?
No. It is a maintenance medication used after withdrawal.
Can someone drink while taking acamprosate?
It does not cause the disulfiram-type reaction, but it is prescribed to support abstinence and treatment goals should be discussed with the clinician.
Does acamprosate affect the liver?
It is primarily eliminated by the kidneys, which can make kidney function especially important when clinicians decide whether it is appropriate.
Sources
This article is general education and does not replace individualized medical advice.